OF ON GOING PROJECTS
"National Retinoblastoma Project" (ICMR)-Guwahati Site, Centre code
04 since April 2009 to March 2014, just completed
investigator= Dr. (Mrs) Kasturi Bhattacherjee
aims of the research are to start a national retinoblastoma registry where retinoblastoma
cases will be uniformly recorded form various centers treating retinoblastoma.
A retinoblastoma registry form has been designed to include all aspects of retinoblastoma
like child identification data, residence of family, presenting illness, the staging
using a common staging system , the examination under anesthesia, family history
of cancer and retinoblastoma . The uniform histopathology of the enucleated eye
or post- chemotherapy enucleated eye will be studied. The management how it was
done by the multiple modalities is also being recorded . Follow up and survival
of the patients is also being recorded.
of research proposal is that RB is a curable disease. Pediatric cancers are emerging
a national priority as they are curable in nature. The epidemiology of the disease
has to be studied and this will enable us to identify the research areas in Retinoblastoma
and especially plan strategy to decrease the mortality, decrease enucleation and
decrease the incidence of retinoblastoma over a decade .
2. On -going "Ophthalmic Telepathology Project"
between Sankara Nethralaya, Chennai and Sri Sankaradeva Nethralaya, Guwahati,
Principal investigator= Dr. Dipankar Das from Sri
Telecommunication technologies offer new ways of
delivering health care to individuals in remote communities and usefulness of
telemedicine is increasingly being studies for verity of medical conditions. Telemedicine
technologies are applicable in ophthalmology, because standard ophthalmic instruments
can be modified to capture and store images that can be digitalized and transmitted
for expert evaluation.
Therefore, objectives of telepathlogy are to make
service assessable and affordable by reducing travel cost and time for the patients
to give pathologic at remote places access to specialized opinion from experts,
to minimize the delay in diagnosis and help them share their experiences and tom
help in training and research.
We at Sankara Netralaya, Chennai, India and
Sri Sankaradeva Nethralaya, Guwahati Assam are perusing through a static telepathology
project. The benefit expected by introduction of this telepathology unit are better
medical service, more distributed speclialization, conservation of time, money
and increased knowledge sharing.
ICMR sponsored SN-SSN technology transfer project "To train and develop infrastructure
of molecular ophthalmic pathology and rapid diagnosis of ocular infection in a
ophthalmic institute of Assam"
Dr. Harsha Bhattacherjee
A. Research Component with training Component
To understand the pathobiology
of retinoblastoma in the following aspects
a. To study the expression of multidrug
resistant proteins Pgp by immminohistochemistry.
b. To study the expression
of human papilloma Virus 16 and 18 genome in retinoblastoma by nested PCR and
c. to investigate the cell cycle proteins in retinoblastoma.
B. To train technical personel
In ophthalmic pathology, microbiology techniques
and in rapid diagnosis of ophthalmic infectious agents.
C. To develop infrastructure
For ophthalmic pathology laboratory to enable the personel at institute to do
both routine and molecular ophthalmic pathology and also enable them to do molecular
microbiology for rapid diagnostics in ocular infections.
4. DBT funded project: Proteomics
based identification and validation of urinary biomarkers for the Age - Related
Principal investigator= Dr. Harsha Bhattacharjee
Recent advances in the treatment of coroidal neovascualrization (CMV) in age related
macular degeneration (AMD) have dramatically improved the outcome in this late
stage complications. However, they are still remains no effective treatment for
geographic atrophy and apart from general lifestyle advice, there are no specific
interventions to slow or reverse progression from early AMD to late stages of
the disease. Guymer et al [Identification of urinary biomarkers for age related
macular degeneration invest Ophthalmol Vis. Sci. 2011 Apr 15] have identified
urinary pro-inflammatory cytokines, transforming growth factor-ß1, Macrophage
Chemo attractant protein-1 and C3 a-desArg, as potential noninvasive biomarkers
for monitoring AMD.
We would like to validate these urinary biomarkers in
Indian AMD patients. The validation of the urinary biomarker would be done at
three institute - at Sri Sankaradeva Nethralaya, Sankara Netralaya, IOB Bangalore.
and causes of amblyopia in children aged 6 months to 16 years in kamrup (metro)
district". Recently started under ICMR
Dr. (Mrs.) Damaris Magdalene
Amblyopia is a scourge in the society, and
an important public health problem because of the irreparable visual loss it causes
if the child is not treated at the proper time. It affects the social, economical,
behavioral, educational, physical and psychological aspects of a community. The
aim of this project is to determine the prevalence, highlight the magnitude of
the disease and find out the causes of amblyopia in children below 16 years of
age. Also to aid the government to implement health care policy like early vision
screening which is currently hampered by a lack of basic information regarding
the true prevalence of these diseases and the best screening approaches.
6. Srimanta Sankaradeva University of Health Sciences(SSUHS) sponsored project
' Association between Structural and refractive component of eye and Diabetic
Just approved on 21st October 2014
investigator= Dr. Harsha Bhattacharjee
Objective: The objectives of the
present study are to find out -
i. Incidence of diabetic retinopathy in the
ii. Refractive status of the eye affected with diabetic
iii. Association between structural and refractive component
of eye and diabetic retinopathy.
Retinopathy is an important cause of blindness. Individuals with higher axial
length of the eye (myopia) are observed to be at low risk of development of Diabetic
Retinopathy. The exact association between myopia and its structural components
is under evaluation. The aim of the research is to find out the incidence of various
refractive status of the eye in patients with diabetic retinopathy and association
between axial length (AL), anterior chamber depth (ACD) and refractive (Lens biometry
and corneal curvature) components and diabetic retinopathy. Student't' test and
multivarient analysis will be done for testing the statistical significance of
various incidence and associations respectively.
7. Srimanta Sankaradeva University of Health Sciences(SSUHS)
sponsored project 'Correlation of Biochemical Parameters-HBA Ic Lipid Profile
and Apo Lipoprotiens in Adult Diabetic patients with Diabetic Retinopathy'
Just approved on 21st October 2014
Dr. Krishna Gogoi
Objective: The objectives of the present
study are to find out -
To determine the blood Glucose fasting and post prandial,
HBA1c levels, Cholestrol, triglyceride, HDL-C, LDL-C and apolipoproteins A1 and
apo b and Apo-B to Ap-A1 ratio in adult Diabetic patients with Diabetic retinopathy
Compare the association of the above parameters with clinical presentation
of DR and evaluate the above parameters as predictive risk factors.
Diabetic retinopathy (DR) is a multi-
factorial microvascular complication occurring in Diabetic patients which may
lead to different degrees of visual impairment and at times to blindness.
aim is to conduct a prospective cross sectional study of the glycemic control
(fasting and post prandial blood sugar, HBA1c), Cholestrol, triglyceride, HDL-C,
LDL-C, VLDL and Apolipoproteins A1 and B in three groups of adult patients - diabetic
with DR and without DR and patients without Diabetes mellitus (DM) or hypertension
attending Sri Sankardeva Nethralaya, Guwahati during the first year. A thorough
history will be taken. Data will be compiled and analysed in the second year.
will be the first study of this kind from this region which will provide a data
to work on. Considering the rapid spread of global epidemic of Diabetes mellitus
and incidence of DR it will help in controlling risk factors identified.